DCFB 2,4-Dichlorofluorobenzen
2,4-Dichlorofluorobenzene
CAS: 1435-48-9
Molecular Formula: C6H3Cl2F
DCFB 2,4-Dichlorofluorobenzen - Names and Identifiers
| Name | 2,4-Dichlorofluorobenzene |
| Synonyms | - 2,4-Dichloro-1-fluor 2,4-Dichlorofluobenzene 2,4-Dichlorofluorobenzene 1,3-Dichlorofluorobenzene 2,4-dichloro-1-fluorobenzene 1,3-Dichloro-4-fluorobenzene DCFB 2,4-Dichlorofluorobenzen 2,4-Dichloro-1-fluorobenzene 2,4-DICHLOROFLUOROBENZENECIPROFLOXACIN N-[4-(trichloromethylthio)sulfonylphenyl]acetamide |
| CAS | 1435-48-9 |
| EINECS | 406-160-1 |
| InChI | InChI=1/C6H3Cl2F/c7-4-1-2-6(9)5(8)3-4/h1-3H |
DCFB 2,4-Dichlorofluorobenzen - Physico-chemical Properties
| Molecular Formula | C6H3Cl2F |
| Molar Mass | 164.99 |
| Density | 1.409g/mLat 25°C(lit.) |
| Melting Point | -23 °C |
| Boling Point | 172-174°C(lit.) |
| Flash Point | 98°F |
| Water Solubility | insoluble |
| Vapor Presure | 1.35mmHg at 25°C |
| Appearance | clear liquid |
| Specific Gravity | 1.409 |
| Color | Colorless to Light yellow to Light orange |
| BRN | 2500791 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.525(lit.) |
| Physical and Chemical Properties | Density 1.409 melting point -23°C boiling point 172-174°C refractive index 1.5235-1.5255 flash point 36°C water-soluble insoluble |
| Use | As a pesticide, pharmaceutical intermediates, as a new fluoroquinolone antibacterial drug intermediates ciprofloxacin |
DCFB 2,4-Dichlorofluorobenzen - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R38 - Irritating to the skin R48/20/22 - R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S16 - Keep away from sources of ignition. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| HS Code | 29039990 |
| Hazard Note | Irritant |
| Hazard Class | 9 |
| Packing Group | III |
DCFB 2,4-Dichlorofluorobenzen - Nature
Open Data Verified Data
colorless transparent liquid. Freezing point -23 °c, boiling point 169 °c (99. OlkPa), relative density 1.492(20 °c), refractive index 1.5242 (20 °c). Insoluble in water, with benzene, toluene, acetone, ethanol, dichloromethane, ethyl acetate, cyclohexane and other organic solvents miscible.
Last Update：2024-01-02 23:10:35
DCFB 2,4-Dichlorofluorobenzen - Preparation Method
Open Data Verified Data
- 3 the diazotization process of monochloro-4-fluoroaniline is mature, the product quality is good, but the price is high, so it is only used for laboratory synthesis.
- 2,4-= Nitro fluorobenzene chloride method this method is the main production method of 2,4 one two chlorine fluorobenzene, the lowest cost, the best economic benefit.
- chlorination of 3 chloro -4 fluoronitrobenzene the conversion of 3-chloro-4-fluoronitrobenzene was 95%, and the selectivity to 2,4-= chlorofluorobenzene was 90%. If nitric acid chloride is used instead of chlorine in the reaction, the selectivity can be increased to 94.3%.
- 5 monochloro-2-fluoronitrobenzene chlorination the yield of the product was 74.5%.
Last Update：2022-01-01 10:40:29
DCFB 2,4-Dichlorofluorobenzen - Use
Open Data Verified Data
This product is a new generation of anti-infective drug intermediates containing fluoroquinolones ciprofloxacin, ciprofloxacin and so on, can also be used in the synthesis of pesticides.
Last Update：2022-01-01 10:40:29
DCFB 2,4-Dichlorofluorobenzen - Safety
Open Data Verified Data
250kg iron drum packaging.
Last Update：2022-01-01 10:40:30
DCFB 2,4-Dichlorofluorobenzen - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| uses | This product is mainly used for the preparation of antipsychotic drug trihaloperidol, trihaloperidol, the main raw materials of quinolones such as ciprofloxacin are also the intermediates of anti-infective drugs such as ciprofloxacin. At the same time, it is also used for the identification of pesticides, insecticides, ovicidal agents, plastics and resins. 2, 4-dichlorofluorobenzene is an important intermediate for the synthesis of novel antibacterial agents fluoroquinolones. Mainly used for the synthesis of ciprofloxacin and medrofloxacin etc. is the starting material of new drug ciprofloxacin. 2, 4-dichlorofluorobenzene is mainly used as the main raw material for the preparation of trifluropiperidine glass, triflurobutylbenzene, pentafluridine, quinolone-ciprofloxacin, etc, at the same time, it is also used for the identification of pesticides, insecticides, ovicidal agents, plastics and resins. used as pesticide and pharmaceutical intermediate, used as intermediate of ciprofloxacin, a new fluoroquinolone antibacterial agent |
| production method | (1) 3-chloro-4-fluoroaniline diazotization method the process is mature and the product quality is good, but the price is higher, so it is limited to the laboratory synthesis. (2)2, 4-dinitrofluorobenzene chloride method this method is the main production method of 2, 4-dichlorofluorobenzene, with the lowest cost and the best economic benefit. (3) 3-chloro-4-fluoronitrobenzene chlorination method the conversion of 3-chloro-4-fluoronitrobenzene in this method was 95%, and the selectivity to 2, 4-dichlorofluorobenzene was 90%. If nitric acid chloride is used instead of chlorine in the reaction, the selectivity may be increased to 94.3%. (4) 5-chloro-2-fluoronitrobenzene chlorination the yield of the product was 74.5%. |
Last Update：2024-04-09 20:49:11
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